Methyl salicylate is a naturally occurring compound that we will use to produce salicylic acid, which will then be used to make the wonder drug aspirin (acetylsalicylic acid) this is not the source of salicylic acid in the industrial synthesis of aspirin, but it is, nevertheless, a good one for laboratory use. Austin peay state university department of chemistry chem 1121 synthesis of aspirin and oil of wintergreen revision f8 page 2 of 7 methyl salicylate is the active ingredient in oil of wintergreen its synthesis reaction is shown in reaction 2. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples it is the two-step synthesis of aspirin starting from oil of wintergreen the mechanism for this synthesis provides examples of three major classes of.
Aspirin is known to be unstable in the presence of moisture at elevated temperatures at those temperatures, aspirin hydrolyzes (ie, reacts with water) to decompose into salicylic acid and acetic. Synthesis of aspirin and methyl salicylate the two compounds we will be preparing, aspirin (acetylsalicylic acid) and oil of wintergreen (methyl salicylate), are both organic esters. Aspirin (2nd edition) compiled by david lewis edited by colin osborne and maria pack designed by imogen bertin and sara roberts first published by the royal society of chemistry in 1998. Preparation of aspirin 1 purpose: the purpose of this experiment is to prepare acetylsalicylic acid, aka aspirin introduction: an important part of chemistry is the preparation, or synthesis, of compounds from simpler start.
A single-pot procedure for the preparation of methyl salicylate (oil of wintergreen) from commercial aspirin tablets has been developed the synthesis proceeds via a tandem transesterification-fischer esterification using acidic methanol and can be carried out using either conventional or microwave heating. Synthesis of aspirin a lubricant such as hydrogenated vegetable oil, corn starch, and water from the time of ancient greeks to the present, acetylsalicylic acid. After the synthesis of aspirin, the product was recrystallized for purification to rid the product of impurities a major impurity that could be found in the crude product would be unreacted salicylic acid. Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula c 6 h 4 (oh)(co 2 ch 3) it is the methyl ester of salicylic acid it is a colorless, viscous liquid with a sweet odor.
Under reflux- synthesis of salicylic acid from wintergreen oil precious ahmed id# 6463614 section 07, friday afternoon lab experiment performed on: friday, january 19, 2013 lab report submitted on: friday, january 24, 2013 introduction before the synthetic aspirin of today, salicylic acid, which is the important ingredient found in aspirin, was. If aspirin forms in the filtrate in the vacuum flask, transfer the filtrate and aspirin to a beaker, chill in an ice bath, and vacuum filter as before, using a new piece of filter paper dispose of the filtrate in the sink. 1 aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a pain killer salicylic acid, whose name comes from salix, the willow family of plants, was derived from. Aspirin is the ester of salicylic acid and acetic acid (acetyl salicylic acid), whereas oil of wintergreen is the ester of salicylic acid and methanol (methyl salicylate) the chemical name.
The synthesis and analysis of aspirin aspirin, the ubiquitous pain reliever, goes by the chemical name acetylsalicylic acid temperature probe mineral oil. Unformatted text preview: k section experiment 12 the preparation of aspirin and oil of win tergreenzan organic synthesis experiment pre-laboratory questions 1 the following preparatory questions should be answered before coming to lab. Synthesis of salicylic acid from oil of wintergreen 2 an additional step may be added to the synthesis of aspirin: conversion of oil of wintergreen (methyl.
The synthesis of aspirin (its chemical name being acetylsalicylic acid) and of oil of wintergreen (with its chemical name as methyl salicylate) both occur by addition of an ester to the molecules both syntheses have salicylic acid on the reactants side, however differ in the second reactant that 'esterifies' the salicylic acid. Processed it edward stone of oxford university discovered salicylic acid in 1763 from the bark of willow tree4,5,6 aspirin works by suppressing the synthesis of prostaglandins and thromboxanes in the. Synthesis of aspirin can be done by adding 6ml of acetic anhydride and 5 drops of concentrated h2so4 to 3 grams of salicylic acid in a 125ml erlenmeyer flask.
Experiment 3: synthesis of salicylic acid from wintergreen oil purpose: the purpose of this lab was to get students familiar with glass materials often used by organic chemists and how to reflux a mixture and to filter its precipitate, through teaching students how to create salicylic acid from methyl salicylate (wintergreen oil) during the. Part ii: synthesis of wintergreen 1 weigh approximately 1g of salicylic acid and place in a test tube 2 add 10ml of methanol to the test tube and gently shake the test tube until all of the salicylic acid. Synthesis of oil of wintergreen pre- lab discussion: methyl salicylate c 6 h 4 ( ho) cooch 3, also known as salicylic acid methyl ester, oil of wintergreen, is a natural product of many species of plants. Synthesis of aspirin: this lab is very time intensive and you must 'multitask' if you are going to finish the actual reaction to produce the aspirin only takes a minute or two, however, there is a lot of preparation before you are ready to run the reaction.